Endolymphatic Sodium Homeostasis by Extramacular Epithelium of the Saccule
نویسندگان
چکیده
منابع مشابه
Endolymphatic sodium homeostasis by extramacular epithelium of the saccule.
The saccule is a vestibular sensory organ that depends upon regulation of its luminal fluid, endolymph, for normal transduction of linear acceleration into afferent neural transmission. Previous studies suggested that endolymph in the saccule was merely derived from cochlear endolymph. We developed and used a preparation of isolated mouse saccule to measure transepithelial currents from the ext...
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OBJECTIVE To locate components and target proteins of relevance for the cAMP and cGMP signaling networks including cAMP and cGMP phosphodiesterases (PDEs), salt-inducible kinases (SIKs), subunits of Na+, K+-ATPases, and aquaporins (AQPs) in the human saccule. METHODS The human saccule was dissected out during the removal of vestibular schwannoma via the translabyrinthine approach and immediat...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2009
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.3044-09.2009